Funded PhD: The development of protein targeting platinum-based anticancer drugs
This multidisciplinary project aims to develop platinum (Pt)-based complexes that can be used successfully to identify Pt(II) binding proteins via a novel metalloproteomic technique, and (as drug candidates that target and overcome Pt resistance.
- Principal investigator(s) Dr Darren Griffith
- Research theme Cancer, Chemistry and Pharmaceutical Sciences
A Science Foundation Ireland (SFI, FFP-P) funded PhD position is available in the Apjohn Laboratory in the Chemistry Department of RCSI working under the supervision of Dr Darren Griffith.
You will be working on a medicinal inorganic chemistry project. There is an important need to better understand the multifaceted mechanisms of action of Pt drugs and in particular the role that Pt(II) protein binding plays.
This will help identify new druggable targets for the development of next generation Pt drugs. Furthermore the clinical success of existing Pt drugs is limited by intrinsic and acquired resistance.
Strategies to sidestep Pt resistance are urgently required. The project will entail synthetic design, organic and inorganic synthesis and purification of target molecules or complexes.
Tenure: Four years
Start date: 1 September 2023
- Upper Second Class (2.1) honours degree (or equivalent) in chemistry or chemistry-based degree (e.g. chemical biology or medicinal chemistry, etc.)
- Final year chemistry students are encouraged to apply as a provisional offer can be be made subject to the grade requirement outlined being met
Desirable candidate specifications include:
- Candidates should ideally have undergraduate chemistry laboratory experience and undertaken a chemistry-based research project
Applications must include:
- A completed application form
- English language requirements (non-native English speakers are expected to have at least 6.5 in IELTS –academic – or equivalent). Find more information here.
- It is the candidate’s responsibility to ensure the application form is completed in full and on time – late and/or incomplete applications will not normally be assessed.
- Unfortunately, we are unable to provide individual feedback to applicants.
- Shortlisted candidates will be invited for interview – applicants may attend a virtual interview.
- At this stage only successful candidates will be contacted to submit, CV, transcripts and other relevant documentation.
- Only their referees will also be contacted at this stage for a reference.