Identification of platinum (II) binding proteins via a novel metalloproteomic technique

There is an important need to better understand the multifaceted mechanisms of action of platinum (Pt) drugs and in particular the role that Pt(II) protein binding plays. Through the identification of novel protein targets we aim to potentially develop the next generation Pt drugs.

A Science Foundation Ireland (SFI) Frontiers for the Future funded PhD position is available in the Targeted Therapeutics in Cancer Laboratory in the RCSI Department of Physiology and Medical Physics working under the supervision of Dr Triona Ní Chonghaile and Dr Darren Griffith at RCSI.

Furthermore the clinical success of existing Pt drugs is limited by intrinsic and acquired resistance. Strategies to sidestep Pt resistance are urgently required. This multidisciplinary project aims to develop Pt-based complexes that can be used successfully to identify Pt(II) binding proteins via a novel metalloproteomic technique and as drug candidates that target and overcome Pt resistance.

During the project the scholar will gain skills in state-of-the-art techniques including global proteomic analysis and super-resolution imaging along with a series of molecular biology techniques.

This molecular biology project is suited to a highly ambitious, driven student with a research interest in drug target identification, proteomics and cell death.

Tenure: Four years

Start date: 1 October 2023

Specification

Minimum requirements:

  • Upper Second Class (2.1) honours degree (or equivalent) in a relevant subject.
  • Excellent communication skills including both written and oral English. Non-native English speakers are expected to have at least 6.5 in IELTS (academic) or equivalent.

Desirable candidate specifications include:

Previous experience in a molecular biology lab is desirable, but not essential, as you will be supported by a team of both post-doctoral and PhD researchers in an established laboratory.

Application process

Please apply for the research project through the link below.

Applications must include:

Apply now

Application deadline: 7 June 2023

Shortlisting: 9 June 2023

Interviews: 14 June 2023

Please note:

  • It is the candidate’s responsibility to ensure the application form is completed in full and on time – late and/or incomplete applications will not normally be assessed.
  • Unfortunately, we are unable to provide individual feedback to applicants.
  • Shortlisted candidates will be invited for interview (applicants may attend a virtual interview)
  • At this stage only successful candidates will be contacted to submit, CV, transcripts and other relevant documentation.
  • Only their referees will also be contacted at this stage for a reference.